Orthopaedics and Traumatology Research

The Clinic for Orthopaedics and Traumatology has a national and international presence in orthopaedic research that is based on a broad representation of the various subspecialties within this surgical field. Our faculty members are dedicated to development of novel surgical modalities and therapeutic concepts by conducting translational medicine that bridges basic science and clinical practice. We aim to create a rich research environment by promoting active, multidisciplinary cooperation among orthopaedic surgeons, radiologists, engineers, movement scientists, study nurses, biostatisticians and physiotherapists and collaborations with other centers. Fundamental to our research endeavour is providing a stimulating educational environment for students, orthopaedic registrars and researchers. Research at our clinic is organized in the focus areas tissue engineering, clinical research and functional biomechanics.

Tissue Engineering

The ultimate goal of the Tissue Engineering Group is to generate cellular grafts to repair cartilage and bone tissues, as well as complex osteochondral lesions. Beyond a potential clinical use as implants, the engineered constructs also represent invaluable 3D model systems to study progenitor cell differentiation and tissue development. The main scientific questions are related to (i) the functionality of human mesenchymal cells (mature, progenitor, stem cells) for bone and cartilage repair, (ii) the effect of specific chemical and physical environmental factors on skeletal tissue engineering, and (iii) the interaction of different cell types during ex vivo tissue morphogenesis. The projects, at the interface between fundamental research and clinical translation, bring together the competences of biologists, engineers and surgeons. Beyond national (SNSF) and industrial programs, research is funded in the context of European consortia, which favor a strong international networking of the group. More…

Clinical Research

The Clinical Research Group initiates and supports clinical studies and clinical trials within the Clinic for Orthopaedics and Traumatology. A multidisciplinary team of surgeons, biostatisticians, study nurses and regulatory affairs managers ensure highest scientific standards to establish and contribute to national and international databases and registries. Clinical research is prerequisite for the critical evaluation of current practice and base for innovation. We encourage formal literature reviews and retrospective studies as preparation for prospective evaluations and clinical trials, and clinicians from all orthopedic and traumatologic subspecialties contribute to the generating knowledge in several areas of expertise embedded in daily practice. More…

Laboratory for Functional Biomechanics

The Functional Biomechanics Group focuses on understanding the complexity of the human body and its function. In our body, nerves, muscles and the skeletal system work together and form the functional chain of biomechanics. Human function depends on the necessary and desired activity such as daily activities or athletic activities. In our laboratory, we study these interrelationships and research questions on the initiation, progression and treatment of orthopaedic diseases (e.g. osteoarthritis) and traumotological events (e.g. fractures). Scientists and clinicians work hand in hand to facilitate clinically relevant answers of important questions and to fulfill our treatment goal of preserving or restorating optimal function in osteoarthritis, after injury or after joint replacement. Our research is funded by the SNSF and local foundations. More…