Highlights

2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003

 

Highlights 2014

IL-28B is a key regulator of B- and T-cell vaccine responses against influenza
In this study, published in the December 13 issue of PLOS Pathogens, Egli et al. demonstrate that IL-28B is a key regulator of the TH1/TH2 balance during influenza vaccination. These results may show a pathway to blocking IL-28B, offering a novel strategy to augment vaccine responses. Egli A, Santer DM, O'Shea D, Barakat K, Syedbasha M, Vollmer M, Baluch A, Bhat R, Groenendyk J, Joyce MA, Lisboa LF, Thomas BS, Battegay M, Khanna M, Mueller T, Tyrrell DLJ, Houghton M, Humar A, Kumar D. PLoS Pathog. 2014 Dec; 10(12):e1004556.

 

Surgical and antimicrobial treatment of prosthetic vascular graft infections at different surgical sites: a retrospective study of treatment outcomes
There are only few studies existing on surgical and antimicrobial treatment of prosthetic vascular graft infections at different surgical sites. Erb et al. investigated 61 patients with vascular graft infections and showed marked differences for different sites, i.e. thoracic, abdominal or peripheral-arterial prosthetic vascular graft infections. In the uni- and multivariate analysis, the type of surgical intervention used in managing infections (graft retention versus graft replacement) did not affect primary outcome, whereas a rifampicin-based antimicrobial regimen was associated with a higher cure rate. This study implies that future studies should differentiate this type of infection according to the location of the grafts and that rifampicin-based antimicrobial regiments should be evaluated. Erb S, Sidler JA, Elzi L, Gurke L, Battegay M, Widmer AF, Weisser M. PLoS One. 2014 Nov 13;9(11):e112