Journal Club

 

2015


A Multicenter Randomized Trial of Continuous versus Intermittent β-Lactam Infusion in Severe Sepsis

21.12.2015 (Veronika Bättig)
Dulhunty J. et al.: A Multicenter Randomized Trial of Continuous versus Intermittent β-Lactam Infusion in Severe Sepsis Am J Respir Crit Care Med. 192 1298-1305 2015

The association between sterilizing activity and drug distribution into tuberculosis lesions

14.12.15 (Daniela Zwisler)
Prideaux B et al.: The association between sterilizing activity and drug distribution into tuberculosis lesions Nat Med 21 1223-7 2015

Behaviorally Assessed Sleep and Susceptibility to the Common Cold

07.12.2015 (Julian Claas)
Prather A. et al. Behaviorally Assessed Sleep and Susceptibility to the Common Cold SLEEP 38 1353-1359 2015

Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study

30.11.2015 (Stefan Erb)
Yi-Yun Liu et al.: Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study Lancet Inf Dis published online 18.11.2015 1-8 2015

Safety and immunogenicity of double-dose versus standart-dose hepatitis B revaccination in non-responding adults with HIV-1 (ANRS HB04 B-BOOST): a multicentre, open-label, randomised trial

23.11.2015 (Florian Banderet-Uglioni)
Rey D. et al.: Safety and immunogenicity of double-dose versus standart-dose hepatitis B revaccination in non-responding adults with HIV-1 (ANRS HB04 B-BOOST): a multicentre, open-label, randomised trial Lancet 15 1283-1291 2015

Efficacy and Safety of the Mosquitocidal Drug Ivermectin to Prevent Malaria Transmission After Treatment: A Double-Blind, Randomized, Clinical Trial

16.11.2015 (Patrick Gubser)
Lin Ouédraogo A. et al.: Efficacy and Safety of the Mosquitocidal Drug Ivermectin to Prevent Malaria Transmission After Treatment: A Double-Blind, Randomized, Clinical Trial CID 60 357-65 2015

Study of Ebola Virus Disease Survivors in Guinea

09.11.2015 (Marcel Stöckle)
Quareshi A. et al.: Study of Ebola Virus Disease Survivors in Guinea CID 61 1035-42 2015

Invasive Pneumococcal Disease Among Immunocompromised Persons: Implications for Vaccination Programs

02.11.2015 (Christian Theilacker)
Shigayeva et al.: Invasive Pneumococcal Disease Among Immunocompromised Persons: Implications for Vaccination Programs. Clin Infect Dis Ahead of print 1-10 2015

A Cross Sectional Analysis of Gonococcal and Chlamydial Infections among Men-Who-Have-Sex-with-Men in Cape Town, South Africa

26.10.2015 (Hanni Bartels)
Kevin Rebe: A Cross Sectional Analysis of Gonococcal and Chlamydial Infections among Men-Who-Have-Sex-with-Men in Cape Town, South Africa PLoS ONE 10(9) e0138315 2015

Shortening Isolation of Patients With Suspected Tuberculosis by Using Polymerase Chain Reaction Analysis: A Nationwide Cross-sectional Study

19.10.2015 (Bloch-Infanger, Constantine)
Fløe A. et al.: Shortening Isolation of Patients With Suspected Tuberculosis by Using Polymerase Chain Reaction Analysis: A Nationwide Cross-sectional Study CID 61 1365-1373 2015

Skin antisepsis with chlorhexidine-alcohol versus povidone iodine-alcohol, with and without skin scrubbing, for prevention of intravascular-catheter-related infection (CLEAN): an open-label, multicentre, randomised, controlled, two-by-two factorial trial

12.10.2015 (Richard Kühl)
Mimoz O. et al.: Skin antisepsis with chlorhexidine-alcohol versus povidone iodine-alcohol, with and without skin scrubbing, for prevention of intravascular-catheter-related infection (CLEAN): an open-label, multicentre, randomised, controlled, two-by-two factorial trial Lancet ePub (ahead of print): September 18 Nicht anwendbar, da ePub (ahead of print) 2015

Maternal and neonatal consequences of treated and untreated asymptomatic bacteriuria in pregnancy: a prospective cohort study with an embedded randomised controlled trial

05.10.2015 (Benedikt Wiggli) Kazemier BM et al. Maternal and neonatal consequences of treated and untreated asymptomatic bacteriuria in pregnancy: a prospective cohort study with an embedded randomised controlled trial Lancet Infect Dis pii: S1473-3099(15)00070-5 [Epub ahead of print] 2015

Healthcare-associated prosthetic heart valve, aortic vascular graft, and disseminated Mycobacterium chimaera infections subsequent to open heart surgery

21.09.2015 (Daniel Goldenberger)
Kohler P et al.: Healthcare-associated prosthetic heart valve, aortic vascular graft, and disseminated Mycobacterium chimaera infections subsequent to open heart surgery European Heart J Jul 17. pii: ehv342. [Epub ahead of print] 2015

Systemic Inflammatory Response Syndrome Criteria in Defining Severe Sepsis

14.09.2015 (Daniela Zwisler)
Kaukonen K. et al.: Systemic Inflammatory Response Syndrome Criteria in Defining Severe Sepsis NEJM 372 1629-1638 2015

Circulating Biomarkers for Discrimination Between Aseptic Joint Failure, Low-Grade Infection, and High-Grade Septic Failure

07.09.2015 (Julian Claas)
Max Ettinger Circulating Biomarkers for Discrimination Between Aseptic Joint Failure, Low-Grade Infection, and High-Grade Septic Failure CID 015;61(3) 332–41 2015

Acetylcholine-Synthesizing T cells relay neural signas in a veagus nerve circuit

31.08.15 (Patrick Gubser)
Rosas-Ballina M. et al.: Acetylcholine-Synthesizing T cells relay neural signas in a veagus nerve circuit Science 334 98-101 2011

Asymptomatic Bacteriuria Treatment is Associated with A Higher Prevalence of Antibiotic Resistant Strains in Women with Urinary Tract Infections

24.08.2015 (Veronika Bättig)
Cai T. et al.: Asymptomatic Bacteriuria Treatment is Associated with A Higher Prevalence of Antibiotic Resistant Strains in Women with Urinary Tract Infections Clin Infect Dis Advance Access published August 12, 2015

Efficacy and effectiveness of an rVSV-vectored vaccine expressing Ebola surface glycoprotein: interim results from the Guinea ring vaccination cluster-randomised trial

17.08.2015 (Stefan Erb)
Ana Maria Henao-Restrepo et al: Efficacy and effectiveness of an rVSV-vectored vaccine expressing Ebola surface glycoprotein: interim results from the Guinea ring vaccination cluster-randomised trial The Lancet Published Online July 31, 2015 http://dx.doi.org/10.1016/S0140-6736(15)61117-5 1-10 2015

Initiation of Antiretroviral Therapy in Early Asymptomatic HIV Infection.

10.08.2015 (Christian Theilacker)
INSIGHT START Study Group
Initiation of Antiretroviral Therapy in Early Asymptomatic HIV Infection.
N Engl J Med. Ahead of publishing 2015

Efficacy of 400 mg efavirenz versus standard 600 mg dose in HIV-infected, antiretroviral-naive adults (ENCORE1): a randomised, double-blind, placebo-controlled, non-inferiority trial

03.08.2015 (Hanni Bartels)
Carey et al.: Efficacy of 400 mg efavirenz versus standard 600 mg dose in HIV-infected, antiretroviral-naive adults (ENCORE1): a randomised, double-blind, placebo-controlled, non-inferiority trial Lancet Infect Dis 2015 15 793-802 2015

Intravenous Immunoglobulin and Mortality in Pneumonia Patients With Septic Shock: An Observational Nationwide Study

27.07.2015 (Matthias von Rotz)
Tagami et al.: Intravenous Immunoglobulin and Mortality in Pneumonia Patients With Septic Shock: An Observational Nationwide Study
CID (Clinical Infectious Diseases) 61(3) 385-392

Clinical Outcomes Associated With Respiratory Virus Detection Before Allogeneic Hematopoietic Stem Cell Transplant

20.07.2015 (Matyas Ecsedi)
Campbell. et al.: Clinical Outcomes Associated With Respiratory Virus Detection Before Allogeneic Hematopoietic Stem Cell Transplant CID 61 192-202

Herpes Simplex Encephalitis: Lack of Clinical Benefit of Long-term Valacyclovir Therapy

13.07.2015 (Michael Osthoff)
Gnann JW Jr et al.: Herpes Simplex Encephalitis: Lack of Clinical Benefit of Long-term Valacyclovir Therapy Clin Infect Dis Epub ahead of print, May 8 2015

High-Dose Oral Amoxicillin Plus Probenecid Is Highly Effective for Syphilis in Patients With HIV Infection.

06.07.2015 (Elisabeth Wehrle)
Tanizaki, R. et al.: High-Dose Oral Amoxicillin Plus Probenecid Is Highly Effective for Syphilis in Patients With HIV Infection. CID 61 177-183 2015

Predicting Risk of Endocarditis Using a Clinical Tool (PREDICT): Scoring System to Guide Use of Echocardiography in the Management of Staphylococcus aureus Bacteremia

29.06.2015 (Benedikt Wiggli)
Bharath Raj Palraj et al.: Predicting Risk of Endocarditis Using a Clinical Tool (PREDICT): Scoring System to Guide Use of Echocardiography in the Management of Staphylococcus aureus Bacteremia Clin Infect Dis 61 18-28 2015

Frequency and Spectrum of Unexpected Clinical Manifestations of Primary HIV-1 Infection

15.06.2015 (Florian Banderet-Uglioni)
Braun D. et al.: Frequency and Spectrum of Unexpected Clinical Manifestations of Primary HIV-1 Infection Clin Infect Dis. [Epub ahead of print] May 19 2015

Trial of Short-Course Antimicrobial Therapy for Intraabdominal Infection

08.06.2015 (Richard Kühl)
Sawyer, R.G. et al.: Trial of Short-Course Antimicrobial Therapy for Intraabdominal Infection NEJM 372 1996-2005 2015

Delayed haemolysis after artesunate treatment of severe malaria – Review of the literature and perspective

01.06.2015 (Marcel Stöckle)
Rolling T.: Delayed haemolysis after artesunate treatment of severe malaria – Review of the literature and perspective Travel Medicine and Infectious Disease 13 143 - 149


Efficacy of an Adjuvanted Herpes Zoster Subunit Vaccine in Older Adults.


18.05.2015 (Christian Theilacker)
Lal, H. et al.: Efficacy of an Adjuvanted Herpes Zoster Subunit Vaccine in Older Adults.
N Engl J Med 28. April (ahead of print) 1 - 10 2015

Oral, Capsulized, Frozen Fecal Microbiota Transplantation for Relapsing Clostridium difficile Infection

04.05.2015 (Constantine Bloch-Infanger)
Youngster I. et al.: Oral, Capsulized, Frozen Fecal Microbiota Transplantation for Relapsing Clostridium difficile Infection
JAMA 2014; 312 (17) 1772-1778 2014

Phase 1 Trials of rVSV Ebola Vaccine in Africa and Europe-Preliminary Report

20.04.2015 (M. von Rotz)
S.T. Agnandji et al.: Phase 1 Trials of rVSV Ebola Vaccine in Africa and Europe-Preliminary Report
N Engl J Med April 1, 2015 (published online)

Antibiotic treatment strategies for community-acquired pneumonia in adults

13.04.2015 (Veronika Bättig)
Postma DF et al.: Antibiotic treatment strategies for community-acquired pneumonia in adults N Engl J Med 372 1312-23 2015

Impact of same-day antibiotic susceptibility testing on time to appropriate antibiotic treatment of patients with bacteraemia: a randomised controlled trial

30.03.2015 (Reno Frei)
Beuving J. et al.: Impact of same-day antibiotic susceptibility testing on time to appropriate antibiotic treatment of patients with bacteraemia: a randomised controlled trial Eur J Clin Microbiol Infect Dis 34 831-838

Polysaccharide Conjugate Vaccine against Pneumococcal Pneumonia in Adults

23.03.2015 (Benedikt Wiggli)
M.J.M. Bonten et al.: Polysaccharide Conjugate Vaccine against Pneumococcal Pneumonia in Adults N Engl J Med 372 1114-25 2015

Long-Term Efficacy of a Hepatitis E Vaccine

16.03.2015 (Adrian Schibli)
Jun Zhang, Xue-Feng Zhang, et al.: Long-Term Efficacy of a Hepatitis E Vaccine NEJM, 5. March 2015 372 914-922 2015

The predictive value of prior colonization and antibiotic use for 3rd generation cephalosporin resistant Enterobacteriaceae bacteremia in patients with sepsis

09.03.2015 (Matyas Ecsedi)
Wouter C. et al.: The predictive value of prior colonization and antibiotic use for 3rd generation cephalosporin resistant Enterobacteriaceae bacteremia in patients with sepsis CID Advance online access - 2015

Combination Antifungal Therapy for Invasive Aspergillosis. A Randomized Trial

02.03.2015 (Nina Khanna)
Marr KA et al.: Combination Antifungal Therapy for Invasive Aspergillosis. A Randomized Trial Annals of Internal Medicine 162 81-89 2015

Tenofovir-Based Preexposure Prophylaxis for HIV Infection among African Women

16.02.2015 (Elisabeth Wehrle-Wieland)
Marrazzo J et al.: Tenofovir-Based Preexposure Prophylaxis for HIV Infection among African Women NEJM 372 No. 6 509-518 2015

Travel-associated infection presenting in Europe (2008–12): an analysis of EuroTravNet longitudinal, surveillance data, and evaluation of the effect of the pre-travel consultation

09.02.2015 (Hanni Bartels)
Patricia Schlagenhauf: Travel-associated infection presenting in Europe (2008–12): an analysis of EuroTravNet longitudinal, surveillance data, and evaluation of the effect of the pre-travel consultation Lancet Infect Dis 2014 Volume 15, No. 1 p55–64 January 2015

A new antibiotic kills pathogens without detectable resistance

02.02.2015 (Richard Kühl)
Ling et al.: A new antibiotic kills pathogens without detectable resistance Nature 517 455-459 2015

Adjunct prednisone therapy for patients with community-acquired pneumonia: a multicentre, double-blind, randomised, placebo-controlled trial.

26.01.2015 (Florian Banderet-Uglioni)
Blum C. et al.: Adjunct prednisone therapy for patients with community-acquired pneumonia: a multicentre, double-blind, randomised, placebo-controlled trial. Lancet Jan 16 1-8 2015

Clinical Efficacy of Polyspecific Intravenous Immunoglobulin Therapy in Patients With Streptococcal Toxic Shock Syndrome: A Comparative Observational Study.

19.01.2015 (Christian Theilacker)
Linner A.: Clinical Efficacy of Polyspecific Intravenous Immunoglobulin Therapy in Patients With Streptococcal Toxic Shock Syndrome: A Comparative Observational Study. Clin Infect Dis 59 851–857 2014

Investigating the zoonotic origin of the West African Ebola epidemic

12.01.2015 (Sarah Tschudin Sutter)
Marí Saéz A. et al.: Investigating the zoonotic origin of the West African Ebola epidemic EMBO Mol Med. 7 17-23 2014