Journal Club

2018


A Randomized, Placebo-controlled Trial of Fidaxomicin for Prophylaxis of Clostridium difficile–associated Diarrhea in Adults Undergoing Hematopoietic Stem Cell Transplantation

17.12.2018 (Silvio Ragozzino)
Mullane KM. et al.: A Randomized, Placebo-controlled Trial of Fidaxomicin for Prophylaxis of Clostridium difficile–associated Diarrhea in Adults Undergoing Hematopoietic Stem Cell Transplantation Clin Infect Dis. [Epub ahead of print] 2018

Effectivness of a group B outer membrane vesicle meningococcal vaccine against gonorhoea in New Zealand: a retrospective case-control study

10.12.2018 (Marcel Stöckle)
Petousis-Harris H. et al.: Effectivness of a group B outer membrane vesicle meningococcal vaccine against gonorhoea in New Zealand: a retrospective case-control study Lancet 390 1603-10 2017

Multicenter Trial of a Combination Probiotic for Children with Gastroenteritis

03.12.2018 (Aurélien Martinez)
Freedman et al.: Multicenter Trial of a Combination Probiotic for Children with Gastroenteritis NEJM 379 2015-2026 2018

Urine Antigen Detection as an Aid to Diagnose Invasive Aspergillosis

26.11.2018 (Sarah Dräger)
Kieren A. Marr: Urine Antigen Detection as an Aid to Diagnose Invasive Aspergillosis CID 67 1705-1711 2018

Prednisone for the Prevention of Paradoxical Tuberculosis-Associated IRIS

19.11.2018 (Maja Weisser)
Meintjes G: Prednisone for the Prevention of Paradoxical Tuberculosis-Associated IRIS NEJM 379 1915-1925 2018

Effect of Increased Daily Water Intake in Premenopausal Women With Recurrent Urinary Tract Infections: A Randomized Clinical Trial

12.11.2018 (Milena Junker)
Hooton T. et al: Effect of Increased Daily Water Intake in Premenopausal Women With Recurrent Urinary Tract Infections: A Randomized Clinical Trial JAMA Intern. Med. 178 1509-1515 2018

Cefiderocol versus imipenem-cilastatin for the treatment of complicated urinary tract infections caused by Gram-negative uropathogens: a phase 2, randomised, double-blind, non-feriority trial

05.11.2018 (Sylvain Meylan)
Portsmouth S.: Cefiderocol versus imipenem-cilastatin for the treatment of complicated urinary tract infections caused by Gram-negative uropathogens: a phase 2, randomised, double-blind, non-feriority trial Lancet Published online October 25 2018 1 -10 2018

Prehospital antibiotics in the ambulance for sepsis: a multicentre, open label, randomised trial

22.10.2018 (Andrea Büchler)
Alam N. et al.: Prehospital antibiotics in the ambulance for sepsis: a multicentre, open label, randomised trial Lancet Respir Med 6 40-50 2018

Phase 2b placebo-controlled trial of M72/AS01E candidate vaccine to prevent active tuberculosis in adults

15.10.2018 (Kai-Manuel Adam)
Olivier Van Der Meeren et al.: Phase 2b placebo-controlled trial of M72/AS01E candidate vaccine to prevent active tuberculosis in adults N Engl J Med. 379 1621-1634 2018

Effect of Piperacillin-Tazobactam vs Meropenem on 30-Day Mortality for Patients With E coli or Klebsiella pneumonia Bloodstream Infection and Ceftriaxone Resistance

08.10.2018 (Fabian Franzeck)
Harris P et. Al.: Effect of Piperacillin-Tazobactam vs Meropenem on 30-Day Mortality for Patients With E coli or Klebsiella pneumonia Bloodstream Infection and Ceftriaxone Resistance JAMA 320 984-94 2018

Development and Validation of a Prediction Model for Mortality and Adverse Outcomes Among Patients With Peripheral Eosinopenia on Admission for Clostridium difficile Infection

24.09.2018 (Sylvain Meylan)
Kulaylat A.S. et al.: Development and Validation of a Prediction Model for Mortality and Adverse Outcomes Among Patients With Peripheral Eosinopenia on Admission for Clostridium difficile Infection JAMA Surgery Ahead of publication E1-7 2018

Partial Oral versus Intravenous Antibiotic Treatment of Endocarditis

10.09.2018 (Sarah Dräger)
Iversen, Kasper: Partial Oral versus Intravenous Antibiotic Treatment of Endocarditis NEJM 10. DOI: 10.1056/NEJMoa1808312 1-10 2018

Antimalarial activity of single-dose DSM265, a novel plasmodium dihydroorotate dehydrogenase inhibitor, in patients with uncomplicated Plasmodium falciparum or
Plasmodium vivax malaria infection: a proof-of-concept, open-label, phase 2a stud

27. 08.2018 (von Rotz Matthias)
Llanos-Cuentas A. et al.: Antimalarial activity of single-dose DSM265, a novel plasmodium dihydroorotate dehydrogenase inhibitor, in patients with uncomplicated Plasmodium falciparum or Plasmodium vivax malaria infection: a proof-of-concept, open-label, phase 2a study Lancet Infect Dis 18: 874-83 2018

Outbreak of vancomycin-resistant Enterococcus faecium
clone ST796, Switzerland, December 2017 to April 2018

20.08.2018 (Alexander Schweiger)
Wassilew N. et al.: Outbreak of vancomycin-resistant Enterococcus faecium
clone ST796, Switzerland, December 2017 to April 2018
Euro Surveill 23 pii=1800351 2018

Inactivated varicella zoster vaccine in autologous haemopoietic stem-cell transplant recipients: an international, multicentre, randomised, double-blind, placebo-controlled trial

13.08.2018 (Aurélien Emmanuel Martinez)
Winston D. et al.: Inactivated varicella zoster vaccine in autologous haemopoietic stem-cell transplant recipients: an international, multicentre, randomised, double-blind, placebo-controlled trial
Lancet 391 2116-27 2018

Four Months of Rifampin or Nine Months of Isoniazid for Latent Tuberculosis in Adults

06.08.2018 (Niklaus Labhardt)
Menzies D et al.: Four Months of Rifampin or Nine Months of Isoniazid for Latent Tuberculosis in Adults NEJM 379 440-453 2018

Cap-Dependent Endonuclease Inhibitor S-033188 for theTreatment of Influenza: Results from a Phase 3, Randomized, Double-Blind, Placebo- and Active-Controlled Study in Otherwise Healthy
Adolescents and Adults with Seasonal Influenza

16.07.2018 (Andrea Büchler)
S. Portsmouth et al.: Cap-Dependent Endonuclease Inhibitor S-033188 for theTreatment of Influenza: Results from a Phase 3, Randomized, Double-Blind, Placebo- and Active-Controlled Study in Otherwise Healthy Adolescents and Adults with Seasonal Influenza Oral Abstract Session, ID Week 2017 2017

Infective Endocarditis in Patients With Bicuspid Aortic Valve or Mitral Valve Prolapse.

09.07.2018 (Parham Sendi)
Zegri-Reiriz I. et al.: Infective Endocarditis in Patients With Bicuspid Aortic Valve or Mitral Valve Prolapse. J Am Coll Cardiol. 71 2731-2740 2018

Comparing the Outcomes of Adults With Enterobacteriaceae Bacteremia Receiving Short-Course Versus Prolonged-Course Antibiotic Therapy in a Multicenter, Propensity Score–Matched Cohort

02.07.2018 (Kai-Manuel Adam)
Darunee Chotiprasitsakul, et al.: Comparing the Outcomes of Adults With Enterobacteriaceae Bacteremia Receiving Short-Course Versus Prolonged-Course Antibiotic Therapy in a Multicenter, Propensity Score–Matched Cohort Clin Infect Dis. 6 172-177 2018

Long term survival, health, social functioning, and education in patients with European Lyme Neuroborreliosis: nationwide
Population based cohort study

25.06.2018 (Fabian Franzeck)
Obel N. et al.: Long term survival, health, social functioning, and education in patients with European Lyme Neuroborreliosis: nationwide
Population based cohort study
BMJ 361 k1998 2018

Azole Resistance of Environmental and Clinical Aspergillus fumigatus Isolates from Switzerland

11.06.2018 (Daniel Goldenberger)
Riat A et al.: Azole Resistance of Environmental and Clinical Aspergillus fumigatus Isolates from Switzerland Antimicrob Agents Chemother 62 E02088-17 2018

A new class of synthetic retinoid antibiotics effective against bacterial persisters

04.06.2018 (Sylvain Meylan)
Wooseong K. et al.: A new class of synthetic retinoid antibiotics effective against bacterial persisters. Nature 556 103-107 2018

Determinants of antibody persistence across doses and continents after single-dose rVSV-ZEBOV vaccination for Ebola virus disease: an observational cohort study

28.05.2018 (Sarah Dräger)
Angela Huttner: Determinants of antibody persistence across doses and continents after single-dose rVSV-ZEBOV vaccination for Ebola virus disease: an observational cohort study Lancet Infect Diseases 18 1-11 S1473-3099(18)30165-8 2018

Acetaminophen as a renoprotective adjunctive treatment in patients with severe and moderately severe falciparum malaria: a randomized, controlled, open-label tria

14.05.2018 (Marcel Stöckle)
Plewes K. et al.: Acetaminophen as a renoprotective adjunctive treatment in patients with severe and moderately severe falciparum malaria: a randomized, controlled, open-label trial CID DOI: 10.1093/cid/ciy213 2018

Effect of 5-Day Nitrofurantoin vs Single-Dose Fosfomycin on Clinical Resolution of Uncomplicated Lower Urinary Tract Infection in Women

07.05.2018 (Reto Thoma)
Huttner A, MD et al.: Effect of 5-Day Nitrofurantoin vs Single-Dose Fosfomycin on Clinical Resolution of Uncomplicated Lower Urinary Tract Infection in Women JAMA 319(17) 1781-1789 2018

Comparison of dynamic monitoring strategies based on CD4 cell counts in virally suppressed, HIIV-positive individuals on combination antiretroviral therapy in high-income countries: a prospective, observational study

16.04.2018 (Maja Weisser Rohacek)
Caniglia EC: Comparison of dynamic monitoring strategies based on CD4 cell counts in virally suppressed, HIIV-positive individuals on combination antiretroviral therapy in high-income countries: a prospective, observational study Lancet HIV 4 E251-59 2017

Post-exposure prophylaxis with doxycycline to prevent sexually transmitted infections in men who have sex with men: an open-label randomised substudy of the ANRS IPERGAY trial


09.04.2018 (Aurélien Martinez)
Molina J et al.: Post-exposure prophylaxis with doxycycline to prevent sexually transmitted infections in men who have sex with men: an open-label randomised substudy of the ANRS IPERGAY trial Lancet infect dis 18 308–17 2018


Effect of Meropenem-Vaborbactam vs Piperacillin-Tazobactam on Clinical Cure or Improvement and Microbial Eradication in Complicated Urinary Tract Infection


26.03.2018 (Sylvain Meylan)
Kaye K.S. et al.: Effect of Meropenem-Vaborbactam vs Piperacillin-Tazobactam on Clinical Cure or Improvement and Microbial Eradication in Complicated Urinary Tract Infection
JAMA

Efficacy, safety, and tolerability of dolutegravir-rilpivirin for the maintenance of virological suppression in adults with HIV-1: phase 3, randomised, non-inferiority SWORD-1 and SWORD-2 studies

12.03.2018 (A. Büchler)
Llibre MJ et al.: Efficacy, safety, and tolerability of dolutegravir-rilpivirin for the maintenance of virological suppression in adults with HIV-1: phase 3, randomised, non-inferiority SWORD-1 and SWORD-2 studies Lancet
http://dx.doi.org/10.1016/S0140-6736(17)33095-7

Trends in Pricing and Generic Competition Within the Oral Antibiotic Drug Market in the United States

05.03.2018 (Sarah Dräger)
Jonathan D. Alpern: Trends in Pricing and Generic Competition Within the Oral Antibiotic Drug Market in the United States CID 65 1848-52 2017


Colistin alone versus colistin plus meropenem for treatment of severe infections caused by carbapenem-resistant Gram-negative bacteria: an open-label, randomised controlled trial


26.02.2018 (Niklaus D Labhardt)
Mical P. et al.: Colistin alone versus colistin plus meropenem for treatment of severe infections caused by carbapenem-resistant Gram-negative bacteria: an open-label, randomised controlled trial The Lancet Infectious diseases

Effect of procalcitonin-guided antibiotic treatment on mortality in acute respiratory infections: a patient level meta-analysis

 


12.02.2018 (Reto Thoma)
P Schütz, Y Witz, R Sager, B Mueller: Effect of procalcitonin-guided antibiotic treatment on mortality in acute respiratory infections: a patient level meta-analysis The Lancet Infectious diseases, 18. January  95-107 2018

Within-host evolution of Enterococcus faecium during longitudinal carriage and transition to bloodstream infection in immunocompromised patients

05.02.2018 (Seth-Smith, Helena)
Moradigaravand D et al: Within-host evolution of Enterococcus faecium during longitudinal carriage and transition to bloodstream infection in immunocompromised patients Genome medicine 9 119 2017

Symptomatic treatment of uncomplicated lower urinary tract infections in the ambulatory setting: randomised, double blind trial

29.01.2018 (Veronika Bättig)
Kronenberg A. et al.: Symptomatic treatment of uncomplicated lower urinary tract infections in the ambulatory setting: randomised, double blind trial BMJ 359 j4784 2017

Depressive Symptoms in Patients Referred to a Tertiary Lyme Center: High Prevalence in Those Without Evidence of Lyme Borreliosis

23.01.18 (Stefan Erb)
Zomer PT et al: Depressive Symptoms in Patients Referred to a Tertiary Lyme Center: High Prevalence in Those Without Evidence of Lyme Borreliosis Clinical Infectious Diseases 65(10) 1689–94 2017

Adjunctive rifampicin for Staphylococcus aureus bacteraemia (ARREST): a multicentre, randomised, double-blind, placebo-controlled trial

15.01.2018 (Fabian Franzeck)
Thwaites GE: Adjunctive rifampicin for Staphylococcus aureus bacteraemia (ARREST): a multicentre, randomised, double-blind, placebo-controlled trial The Lancet Published online 2017

Letermovir Prophylaxis for Cytomegalovirus in Hematopoietic-Cell Transplantation

08.01.2018 (L. Brockhaus)
Marty F.M.: Letermovir Prophylaxis for Cytomegalovirus in Hematopoietic-Cell Transplantation NEJM December 6
DOI: 10.1056/NEJMoa1706640 2017