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Highlights 2009

Self-reported alcohol consumption and its association with adherence and outcome of antiretroviral therapy in the Swiss HIV Cohort Study

Conen A et al. and the Swiss HIV Cohort Study describe in a large observational cohort study that higher alcohol consumption in HIV-infected individuals was associated with several psychosocial and demographic factors, non-adherence to ART and, in pre-treated individuals, being off treatment despite low CD4+ T-cell counts. It is the largest survey on HIV and alcohol consumption.

Article on PubMed Conen A et al., Antivir Ther, 14:349-357, 2009


Prevalence of polyomavirus BK and JC infection and replication in 400 healthy blood donors

In this study Egli A et al. demonstrate important data about polyomavirus infection and replication in healthy, immunocompetent individuals. They found that IgG seroprevalence was 82% for BKV and 58% for JCV. This indicates that important factors such as severe immunosuppression are needed to cause disease.

Article on PubMed Egli A et al., J Infect Dis, 199(6):837-846, 2009


Outcomes of early switching from intravenous to oral antibiotics on medical wards

In this prospective intervention study outcomes of early switching from intravenous to oral antibiotics on medical wards were investigated. Switching criteria were successfully applied to all patients on the wards, independently of the indication, the type of presumed infection, the underlying disease or the group of antibiotics being used.

Article on PubMed Mertz D et al., J Antimicrob Chemother, 64(1):188-199, 2009


Surgical hand antisepsis with alcohol-based hand rub: comparison of effectiveness after 1.5 and 3 minutes of application

The aim of this study was to validate the effectiveness of 1.5 minutes of surgical hand antisepsis in a clinical setting by comparing the effectiveness of 1.5- and 3-minute applications of alcohol-based hand rub. Importantly, a similar bacterial reduction, regardless of whether it was applied for 3 or 1.5 minutes, was reached confirming experimental data generated with healthy volunteers.

Article in PubMed Weber WP et al., Infect Control Hosp Epidemiol, 30(5):420-426, 2009


Exclusive S. aureus throat carriage: at-risk populations

Mertz et al. investigated three groups of individuals in the community (n=2'632) with different estimated levels of exposure to the health care system. This included healthy blood donors, participants from a school of dental medicine, and health care workers at a trade fair. The authors conclude that absence of exposure to the health care system and younger age predicted exclusive throat carriers, a population at high risk for community-onset methicillin-resistant S aureus. Screening for S. aureus should include swabs from the anterior nares and from the throat to improve the likelihood of detecting carriers.

Article on Pubmed Mertz D et al, Arch Intern Med. 2009 Jan 26;169(2):172-8