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Highlights 2012

Determinants of sustained viral suppression in HIV-infected patients with self-reported poor adherence to antiretroviral therapy

In this study we investigated if genetic factors play a favourable role in patients in order to keep the virusload sustained despite poor adherence to antiretroviral therapy. Genetic factors could not be found but additional parameters contributing to good therapeutic response as for example how long the virusload had been suppressed before poor adherence was reported. Glass TR, Rotger M, Telenti A, Decosterd L, Csajka C, Bucher HC, Günthard HF, Rickenbach M, Nicca D, Hirschel B, Bernasconi E, Wandeler G, Battegay M, Marzolini C; Swiss HIV Cohort Study. PLoS One. 2012;7(1):e29186. Epub 2012 Jan 3.


No risk of surgical site infections from residual bacteria after disinfection with povidone-iodine-alcohol in 1014 cases: a prospective observational study

In this study a low rate of surgical site infections was be found if povidoneiodine-alcohol was used preoperatively for desinfection of operational sites. This is an important finding since chlorhexidine-based solutions are used more frequently. Tschudin-Sutter S, Frei R, Egli-Gany D, Eckstein F, Valderrabano V, Dangel M, Battegay M, Widmer AF. Ann Surg. 2012 Mar;255(3):565-9.


Renal function in patients with HIV starting therapy with tenofovir and either efavirenz, lopinavir or atazanavir

This collaborative study of the Swiss HIV-Cohort study demonstrates that Tenofovir co-administered with proteaseinhibitors lead to a greater decline in renal function rather than when co-administered with Efavirenz. Young J, Schäfer J, Fux CA, Furrer H, Bernasconi E, Vernazza P, Calmy A, Cavassini M, Weber R, Battegay M, Bucher HC; Swiss HIV Cohort Study. AIDS. 2012 Mar 13;26(5):567-75.


Dynamics of ampicillin-resistant Enterococcus faecium clones colonizing hospitalized patients: data from a prospective observational study

In this molecular epidemiological study on enterococcus faecium a certain type (MT-159) was found to be the most widespread enterococcus faecium- bacterium. The paper shows that fortunately after hospitalisation ampicillin-resistant bacteria dissappeared however, with the exception of the most common bacterium: MT-159. Weisser M, Oostdijk EA, Willems RJ, Bonten MJ, Frei R, Elzi L, Halter J, Widmer AF, Top J. BMC Infect Dis. 2012 Mar 22;12:68.


Efavirenz in an obese HIV-infected patient - a report and an in vitro-in vivo extrapolation model indicate risk of underdosing.

This case study shows that it is highly likely that the dosage of Efavirenz has to be adjusted in obese HIV-infected patients. In addition to the case study de Roche and Marzolini demonstrate that Efavirenz probably has to be administered in a higher dosage in patients with a BMI of > 35 kg/m2. de Roche M, Siccardi M, Stoeckle M, Livio F, Back D, Battegay M, Marzolini C. Antivir Ther. 2012 Apr 24. doi: 10.3851/IMP2107. [Epub ahead of print]


Choice of Initial Combination Antiretroviral Therapy in Individuals With HIV Infection: Determinants and Outcomes

This study received  a great deal of attention in the media. During 01.01.2005 and 31.12.2009 Elzi et al investigated in a total of 1‘957 patients different factors influencing the choice of initial cART and its outcome. The study shows large differences in prescription but not in outcome among the study sites. The study highlights the need for evidence-based data in order to select the best initial regimen for different HIV-infected patients. Elzi L, Erb S, Furrer H, Ledergerber B, Cavassini M, Hirschel B, Vernazza P, Bernasconi E, Weber R, Battegay M; for the Swiss HIV Cohort Study. Arch Intern Med. 2012 Aug 13:1-9. doi: 10.1001/archinternmed.2012.3216. [Epub ahead of print]

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