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Highlights 2013

Decreasing mortality and changing patterns of causes of death in the Swiss HIV Cohort Study

In this study the mortality among HIV-infected persons was investigated within the framework of the Swiss HIV-Cohort Study. AIDS-related mortality was highest in 1992 and decreased to 0.44/100 patients per year in 2006. Importantly, between 2005 and 2009, 84% of deaths were non-Aids-related; in particular, Hepatitis B or C co-infections increased the risk of death. This study impressively shows the advances of HIV-treatment also the upcoming importance of co-infections and co-morbidity. Weber R, Ruppik M, Rickenbach M, Spoerri A, Furrer H, Battegay M, Cavassini M, Calmy A, Bernasconi E, Schmid P, Flepp M, Kowalska J, Ledergerber B; Swiss HIV Cohort Study (SHCS). HIV Med. 2013;14(4):195-207.


Increasing prevalence of ciprofloxacin resistance in extended-spectrum-β-lactamase-producing Escherichia coli urinary isolates.

In this study the authors describe during a 10 years period the incidence and drug susceptibility profiles of uropathogenic ESBL-E. coli. They found that these bacteria resistant to many antibiotics are increasing. However, their susceptibility to nitrofurantoin, fosafomycin and carbapenems is still excellent. This study shows that local knowledge of resistant patterns is very important to treat patients with antibiotics and also to avoid wrong routine antibiotic prophylaxis prior to urological interventions. Bonkat G, Müller G, Braissant O, Frei R, Tschudin-Suter S, Rieken M, Wyler S, Gasser TC, Bachmann A, Widmer AF. World J Urol. 2013 Jan. [Epub ahead of print]


Uptake of guidelines on prevention of mother-to-child transmission of HIV in rural Tanzania: time for change.

In this review Gamell et al describe the guidelines for prevention of mother-to-child transmission of HIV-1. These guidelines are insufficiantly implemented in low – income countries. With the example of Tanzania the authors discuss the likely impact of different strategies for PMTCT. They argue in favour of implementing option B+ in Tanzania which recommends providing lifelong antiretroviral treatment to all HIV-positive pregnant women. The interesting aspect of this article is the identification of different operational gaps in rural Tanzania exemplifying the problems encountered in Sub-Sahara Africa. Gamell A, Letang E, Jullu B, Mwaigomole G, Nyamtema A, Hatz C, Battegay M, Tanner M. Swiss Med Wkly. 2013 Mar;143:0.