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Highlights 2015

Impact of body weight on virological and immunological responses to efavirenz-containing regimens in HIV-infected, treatment-naive adults

In a large observational study, Marzolini et al. investigated close to 20’000 patients in the European COHERE cohort collaboration study. The authors were able to show that virological and immunological responses to initial EFV-containing regimens were not impaired in heavy individuals, suggesting that the standard 600 mg EFV dosage is appropriate across a wide weight range. Marzolini C, Sabin C, Raffi F, Siccardi M, Mussini C, Launay O, Burger D, Roca B, Fehr J, Bonora S, Mocroft A, Obel N, Dauchy FA, Zangerle R, Gogos C, Gianotti N, Ammassari A, Torti C, Ghosn J, Chêne G, Grarup J, Battegay M; Efavirenz, Obesity Project Team on behalf of Collaboration of Observational HIV Epidemiological Research Europe (COHERE) in EuroCoord. AIDS. 2015 Jan 14;29(2):193-200.


A Bundle of Services Increased Ascertainment of Tuberculosis among HIV-Infected Individuals Enrolled in a HIV Cohort in Rural Sub-Saharan Africa

Haraka et al. report on trends of Tuberculosis among HIV-patients in a rural HIV-cohort in Tanzania and assess the impact of a bundle of services implemented in December 2012. This bundle consisted of three components: (i) integration of HIV and tuberculosis services; (ii) GeneXpert for tuberculosis diagnosis; and (iii) electronic data collection. Over 7’000 HIV-positive patients were enrolled in this analysis. Introducing the bundle of services the incident rate of tuberculosis increased dramatically. Independent predictors of Tuberculosis ascertainment were identified. The integration of tuberculosis and HIV services together with comprehensive electronic data collection and use of GeneXpert increased dramatically the ascertainment of tuberculosis in this rural African HIV cohort. Haraka F, Glass TR, Sikalengo G, Gamell A, Ntamatungiro A, Hatz C, Tanner M, Furrer H, Battegay M, Letang E. PLoS One. 2015 Apr 21;10(4):e0123275


Immune Reconstitution After Allogeneic Hematopoietic Stem Cell Transplantation and Association With Occurrence and Outcome of Invasive Aspergillosis

Invasive aspergillosis (IA) remains a leading cause of morbidity and mortality in patients receiving allogeneic hematopoietic stem cell transplantation (HSCT). To date, no reliable immunological biomarkers for management and outcome of IA exist. Here, Stuehler et al. investigated reconstitution of antifungal immunity in patients during the first 12 months after HSCT and correlated it with IA. In this study, 51 patients were analyzed, demonstrating the importance of functional polymorphal nuclear, CD8, CD4 and NK-cells for the outcome of invasive aspergillosis. Stuehler C, Kuenzli E, Jaeger VK, Baettig V, Ferracin F, Rajacic Z, Kaiser D, Bernardini C, Forrer P, Weisser M, Elzi L, Battegay M, Halter J, Passweg J, Khanna N. J Infect Dis. 2015 Mar 6. pii: jiv143